Background and Objective: Sepsis in neonates is difficult to diagnose clinically. When diagnosing neonatal sepsis, physicians frequently utilise biomarkers such as c-reactive protein (CRP). The aim of this study was to investigate the connection between blood culture and CRP levels as a potential early marker of sepsis in neonates. Material and method: The study involved 500 newborns over a seven-month period who were suspected of having neonatal sepsis. Each patient had a blood culture and had their CRP qualitatively assessed. For the individuals who tested positive for CRP, CRP semi-quantification was performed. Result: We found that the culture result for newborn sepsis was positive in 34.6% of cases. The results showed that CRP was a good predictor of sepsis, with sensitivity, specificity, PPV, NPV, and diagnostic accuracy of 69%, 48%, 41%, 74%, and 55%, respectively. Conclusion: Neonatal sepsis can be diagnosed quickly with the use of CRP estimate, a quick test with good sensitivity.