Background: Diaphyseal fractures of humerus accounts for 3% of all fractures1. Most of the fractures occur in young individuals because of increasing road traffic accidents. These diaphyseal fractures have been treated conservatively since ages but surgery is indicated for optimum outcome. With the advancement of the surgical techniques and instruments, operative management of humeral shaft fractures has increasingly become accepted2,3. The optimal method of humeral shaft fracture fixation remains in debate. This study was conducted to evaluate the outcome of the results of intramedullary nailing and dynamic compression plate fixation. Materials and methods: A prospective, comparative study was conducted in Department of Orthopaedics, Chirayu Medical College And Hospital ,Bhopal M.P from December 2021 to January 2023 consisted of 40 cases of fracture shaft humerus divided in two groups of 20 each to which closed interlocking nail and open dynamic compression plate was done. Study results were evaluated with ASES score. The results were analysed on the parameters of sex, age, mode of trauma, rate of healing, functional outcome, complications and morbidity. Results: The study included patients 18 years and above in age. The age of the patients ranged from 18- 63 years. The commonest age group affected was 18-25 years and maximum number of patients were below the age of 45 years. The mean age affected was 37.7 years. Male predominance of 65% sean with male:female ratio 1.9:1, more common on left side 55%, road traffic accident (RTA) in 88% cases as common mode of injury followed by fall, most common AO type A3 37.5% cases, interlocking nail group showed 60% cases as excellent result 30% cases showed good results and 10% showed fair results and with compression plating 90% cases had excellent result and 10% cases showed good results. Conclusion: We observed no significant difference in union rates in both groups. Patient’s who was treated with interlocking nailing achieves early union. Interlocking nailing had lower chances of radial nerve injury, however significant shoulder stiffness was noted in that group. Compression plating is standard for diaphyseal shaft humerus and has less post-operative morbidity.