Background:Cardiovascular diseases contribute to 17.5 million deaths per year and depressive disorders are the fourth leading cause of the global disease burden. The present study was conducted to evaluate psychiatric comorbidities in patients with acute coronary syndromes. Materials & Methods:140 patients with ACS of both genderswere assessed on a structured and validated proforma before discharge, at 3 months, and at 6 months. Screening of psychiatric disorders was done using Mini International Neuropsychiatric Interview PLUS 5.0.0 and assessment of depression was done using Hamilton Depression Rating Scale. Results: Out of 140 patients, males were 62 and females were 78. Educationwas illiterate44, primary in 56, high in 24 and degree in 16 patients. Marital status was unmarried in 14, married in 96 and divorced/widow in 30. Occupation was skilled in 25, semi- skilled in 35, unskilledin 75 and students 5. SES was upper in 30, middle in 58 and lower in 52. Domicilewas urban in 48 and rural in 92. The difference was significant (P< 0.05). Diagnosis was STEMI in 95, UNSTEMI in 35 and Unstable Angina in 10 cases. Substance use was alcohol in 48 and smokingin 32. Comorbidities were diabetes in 62 and hypertension in 51. Psychiatric illness was major depressive disorder in 48, major depressive with melancholia in 12, recurrent depressive disorder in 5, dysthymia in 2, bipolar type 1 in 3, social phobia in 6, alcohol abusein 4 and somatization disorders in 2 patients. The difference was significant (P< 0.05). The value for HDRS at baseline was 17.2, at 3 months was 18.9 and at 6 month was 16.3. The difference was significant (P< 0.05). Conclusion: There was high prevalence of psychiatric illness in patients with cardiovasculardiseases. The most common was substance abuse, anxiety, and depression.