Background:Slow deep breathing practices, such as diaphragmatic breathing or paced breathing, have been shown to have beneficial effects on blood pressure and heart rate through various physiological mechanisms. The present study was analysis of slow deep breathing effect on heart rate and the blood pressure. Materials & Methods:110 healthy subjects of both genders were subjected to three months slow deep breathing exercise. Assessment of blood pressure, pulse and respiratory rates was done. Results: The mean pulse rate before deep breathing was 78.4 beats/min in group I and 76.2 beats/min in group II. Respiratory rate was 17.2 cycles/min in group I and 16.8 cycles/min in group II. The mean SBP was 120.5 mm Hg in group I and 118.6 mm Hg in group II, DBP was 78.2 mm Hg in group I and 74.2 mm Hg in group II. The difference was significant (P< 0.05). The mean SBP after deep breathing was 114.5 mm Hg in group I and 112.6 mm Hg in group II, DBP was 78.2 mm Hg in group I and 73.2 mm Hg in group II, pulse rate was 70.4 beats/min in group I and 71.2 beats/min in group II. Respiratory rate was 14.2 cycles/min in group I and 15.1 cycles/min in group II. The difference was significant (P< 0.05). Conclusion: Deep, slow breathing lowers heart rate and blood pressure while enhancing autonomic processes.