Background: Nephrotic syndrome is characterized by substantial proteinuria causing hypoalbuminemia, hyperlipidemia, edema, and diverse complications. This study aimed to explore the clinical profile of nephrotic syndrome and to assess the clinical response to the given treatment. Methods:This prospective hospital-based study was conducted at a tertiary care hospital between December 2014 and 2016. Patients diagnosed with proteinuria, hypoalbuminemia, edema and hyperlipidemia were included in this study. Results:A total of 100 patients, with a mean age of 33.6 years were included. Among these, 88 patients had primary, while12 patients had secondary glomerular disease. Focal segmental glomerulosclerosis(FSGS)was the most common (n=24) primary glomerular lesion. All patients with IgA nephropathy were belonged to the age group of<40 years. Edema was observed in all patients with nephritic syndrome. Microscopic hematuria was present in all patients with diffuse proliferative glomerulonephritis(DPGN). About 86 patients were followed up for > 6 month.Steroid was given in all patients with minimal change disease (MCD), FSGS, membranoproliferative glomerulonephritis (MPGN), immunoglobulin M (IgM) nephropathy, C1q nephropathy and DPGN.Patients with MCD had higher complete remission rate(70.6%). About 50% patients with IgM nephropathy had relapse. Among 86 patients, 7 patients affected with infection. Conclusion:FSGS stands out as the most predominant glomerular lesion among adult with nephrotic syndrome. Patients with MCD typically respond well to treatment, whereas those with DPGN often face a poor prognosis.