Background:Infections account for a significant number of hospital admissions, especially in children, and are a major source of morbidity and mortality in India. The present study was conducted to assess antimicrobials use in Pediatric intensive care unit. Materials & Methods:120 children admitted to Pediatric intensive care unit of both genders were selected. Baseline demographic and clinical features, duration of hospital stay, antimicrobials received was recorded. ADR data were captured on the ADR monitoring form of Pharmacovigilance Programme of India. Results: Out of 120 patients, males were 72 and females were 48. Total antimicrobial prescribed were 280. The mean antimicrobial per patient was 2.3. The mean duration of antimicrobial treatment was 6.5 days. The mean duration of hospital stay was 8.2 days. ADR was reported in 4 cases. Antimicrobials used were Cephalosporin in 45%, Beta Lactams/Vancomycinin 28%, Amikacin in 12%, Metronidazole in 6%, Fluroquinolone in 4%, Macrolides in 3.5%, and Aciclovir in 1.5% cases. The difference was significant (P< 0.05). Conclusion: The most common antimicrobials used were Cephalosporin, Beta Lactams/Vancomycin, Amikacin and Metronidazole.