Aim: The aim of the study was to determine the impact of NSAIDs on the evolution of CFC. Material and methods: The cases incorporated in the series comprised individuals who were hospitalised due to the severeness of the presenting symptoms and were admitted to the emergency department. There were sixty instances of CFC in this category. Results: NSAIDs were utilised by 80% of patients, either through self-medication or by prescription from a community physician, dentist or chemist. The molecules that occurred most frequently were diclofenac and tiaprofenic acid. In the majority of instances, CFC extension was limited to the maxillary and/or ipsilateral subhyoid region; however, there were four catastrophic cases of lower cervical extension and one case of mediastinal involvement. Conclusion: CFC is a critical and potentially fatal infection that signifies an urgent need for both diagnostic and therapeutic interventions. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is often cited as a risk factor; thus, these drugs should be utilised with extreme caution, if at all, in cases of head and neck infections, particularly those of an odonto-stomatological nature.