Sickle cell disease (SCD) is an umbrella term that defines a group of inherited diseases (including sickle cell anaemia (SCA), HbSC and HbSβ-thalassaemia) characterized by mutations in the gene encoding the haemoglobin subunit β. Beta-thalassemia is described by the absence or reduction in the rate of production of the β-globin chain. It was the first time defined by Cooley and Lee in 1925.It is categorized according to decreased (β+) or absent (β0) globin chain production which might lead to microcytic and hypochromic anemia as well as a wide range of syndromicforms.There are evidences of Co-Inheritance of Sickle cell trait and minor βthal mutation (βs/βthal). A 3rdGravida female from Prevalent Tribal Population was referred from the periphery to AGMC & GBPH with complaint of Non-Progression of labour with Severe Anemia.After that patient was investigated for Anemia& sepsis, these were the findings.The Authors diagnosed the case after evaluating the reports of CBC, Hb Electrophoresis & Clinical History as Co-inheritance of Sickle Cell Trait with Beta Thalassemia Trait. HPLC Chromatogram of the Hemoglobin Electrophoresis showed HbF<0.8%, HbA2 5.8%, S-window 16.3%, Hb A0 67.3% & HbA1c 5%& CBC showed Normocytic Normochromic with Anisocytosis. This much severe Anemia is not usually seen in Sickle Cell Trait. Co-inheritence of these two conditions is in itself rare.Early & proper diagnosis is helpful in managing such patients.