Background: Advances in modern healthcare have improved the life expectancy of the population and quality of life of the elderly. Postoperative cognitive dysfunction describes a decline in cognitive ability from a patient's baseline that starts in the days after surgery and is prevalent in 1% of elderly patients after 1 yr. Hence, the present study was conducted for assessing the effect of Intraoperative hypotension with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia for surgery.Materials &Methods: A total of 50 patients of more than 75 years of age and scheduled to undergo elective surgical procedure (non-cardiac) under general anesthesia were enrolled. The following two research groups were randomly assigned to each patient: Patients in Group B were tailored to more lax intraoperative blood pressure control, whereas patients in Group A had a customized intraoperative blood pressure target of mean arterial pressure (MAP) > 90% of preoperative values. Before surgery and for three months following the procedure, a neuropsychologist administered a battery of approved cognition tests. Postoperative delirium and the three-month POCD incidence were evaluated.Results: Average MPA among no-target group and target group was 89.3 mm of Hg and 95.1 mm of Hg respectively. While comparing the results, significant results were obtained. Incidence of POCD and delirium did not differ between groups. No correlation was found between intraoperative hypotension and postoperative cognitive performance or delirium.Conclusion: No correlation exists between intraoperative hypotension with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia for surgery.