Aim:To examine the correlation between the neutrophil lymphocyte ratio (NLR) and patients diagnosed with chronic obstructive pulmonary disease (COPD). Materials and methods: A cohort of 100 patients with COPD was split into two groups, each consisting of 50 individuals.COPD group (n=50): This group consisted of individuals with stable COPD, meaning they had not had any major changes in symptoms and had not required any further treatment for the last three months. AECOPD group (n=50): This group consisted of 50 patients who had Acute Exacerbation of COPD (AECOPD), which is described as a sudden worsening of symptoms in individuals with COPD that need further treatment.Participants (n=50): Individuals who are in good health, have never smoked or been exposed to biomass, do not have any other medical conditions, and do not exhibit any clinical symptoms.Participants' blood samples were obtained and analyzed for total and differential leukocyte count, as well as absolute eosinophil and neutrophil counts. Results: The mean neutrophil-to-lymphocyte ratio (NLR) was substantially greater in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) group (4.21±0.11) compared to the stable COPD group (3.15±0.08). Nevertheless, there was no substantial disparity in the amounts of haemoglobin or the proportion of eosinophils between the two groups. ROC analysis shown that the Neutrophil-to-Lymphocyte Ratio (NLR) had a strong predictive value for exacerbations of Chronic Obstructive Pulmonary Disease (COPD). With a threshold of 3.56, the sensitivity, specificity, and Area Under Curve (AUC) were 76.45%, 71.78%, and 0.56, respectively. Conclusion: Regular and intense flare-ups of COPD have a negative impact on the patient's health and can contribute to the advancement of the illness and increased risk of death. Early identification and treatment of exacerbations may be facilitated by predicting them in advance. Recent research indicates that the Neutrophil-to-Lymphocyte Ratio (NLR) serves as an inflammatory biomarker that experiences a substantial increase during exacerbations of Chronic Obstructive Pulmonary Disease (COPD).