Background: Leprosy is a chronic infectious disease involving skin and peripheral nerves. It is present in different clinico-pathological forms depending upon immune status of the host. Objectives: To study the clinical and Histopathological features in patients of leprosy and to find out the correlation of clinical diagnosis and Histopathological diagnosis. Methods: This was a cross sectional hospital-based study. A detailed clinical history and examination were carried out. Clinical examination included the type, number and site of lesion, type of disease and neural involvement. All the patients were subjected to skin biopsies with routine Haematoxylin and Eosin stains. Results: A total of 80 cases clinically suspected with leprosy were studied. Majority of the patients (40%) were in the 30-45 years of age, predominantly male (63.8%). Most common site of lesion was upper extremities (33.7%) followed by head & neck (21.3%). The common clinical feature was Hypo-anesthetic patch (61.3%) and erythematous plaque (58.7%). The commonest reported histopathological type was borderline Tuberculoid (43.7%) followed by lepromatous leprosy (20%). Correlation between clinical and Histopathological diagnosis for individual type of leprosy was found to be TT (66.7%), BT (68.5%), BB (50%), BL (70%), LL (93.7%) and IL (45.5%). Conclusion: Diagnosing and treating leprosy solely on clinical basis still poses a problem while histopathology helps in making a definite diagnosis. This study shows a good correlation among clinical and Histopathological findings in skin biopsy