Background: This study was conducted to assess the serum lipid profile in patients with oral cancer. Material and methods: There were a total of 100 subjects in the study. In this investigation, subjects with oral cancer confirmed by histology as well as those without any underlying systemic illness were included. Subjects who were overweight or older than 65 were not allowed to participate in the study. The subjects were split into two groups of fifty each, one for each type of oral cancer and one for healthy ones. Fifty people without the condition made up Group 1, while fifty subjects with the disease made up Group 2. Descriptive statistics were employed in this study in order to reach findings. The results for categorical variables are shown as a percentage, and the findings for continuous variables are shown as mean SD (Min-Max).The results are deemed significant at the 5% level of significance. Analysis of variance is performed to compare research parameters among three or more patient groups; the Post hoc test according to Tukey is used to compare pairwise comparisons. The 3x3 Fisher exact test was used to assess the significance of categorical study parameters between two or more groups. The results are deemed significant at the 5% level of significance. Results: The study revealed that the oral cancer group had mean plasma triglyceride levels of 100.01 mg/dl and the control group had mean levels of 163.41 mg/dl. It was discovered that the malignant groups had mean plasma triglyceride levels that were lower than those of the control group. The mean plasma TC level was 136.77 mg/dl in the cancer group and 209.89 mg/dl in the non-cancer group. Compared to the control group, the precancerous and cancerous groups had considerably decreased plasma TC levels. Conclusion: The risk of oral cancer was inversely correlated with serum lipid profile. A decrease in serum lipid levels may be a precursor to changes occurring in cancerous cells, according to some data.