Background: A seizure is defined clinically as a paroxysmal alteration in neurologic function, i.e. motor, behavior and/or autonomic function. It is critical to recognize neonatal seizures to determine their etiology, sometimes requiring specific therapy. Present study was aimed to evaluate serum sodium level in relation with neonatal seizures. Material and Methods:Present study was single-center, prospective, observational study, conducted in neonates with neonatal seizures occurring in the first 4 weeks of life in a full-term baby OR Newborn with history of birth asphyxia, hypoglycemia, hypocalcaemia, CNS infection and sepsis. Serum electrolytes were done on emergency basis, serum calcium, sodium, potassium and chloride were done. Results: Out of 645 newborns delivered, 100 neonates were taken for study who were admitted in NICU for seizure during study period. Incidence of neonatal seizures was 15.50 %. In our study, 47 were males and 53 were female babies with male to female ratio of 1:1.12. In our study onset of seizures on first day of life was seen 40 neonates (40%), on second day of life 30 neonates developed seizures (30%), on third day of life 14 (14%) babies developed convulsions. The first three days of life together constituted 87% of neonatal seizures. 44 neonates had subtle seizures, 29 neonates had generalized tonic seizures, 11 had multifocal clonic seizures and 8 had focal clonic seizures. Birth asphyxia was the commonest cause of neonatal seizures in our study (74%) followed by neonatal meningitis (8%), dehydration (17%) and hypocalcemia (1%). 70 had serum sodium level <130 meq/l (i.e. hyponatraemia), 2 of them had serum sodium >150meq/l (i.e. hypernatraemia) and 28 of them had serum sodium level within normal range (130-150 meq/l). Conclusion: 70 % had hyponatraemia& 2 % had hypernatraemia. Thus, hyponatraemia was significantly seen in cases of neonatal seizures.