Aim:To investigate the impact of smartphone use on cardiovascular and hematological parameters in the adult population. Materials and methods: The sample was obtained from a research population consisting of 130 individuals who had been using mobile phones over the last 4 years and were monitored for the objectives of the study. The individuals' blood pressure was measured in a seated position using a Sphygmomanometer (Mercury). The total white blood cell count was determined using the Haemocytometer technique, with Turk's fluid used as the diluent. The respondents' mobile phone use duration, measured in hours, was taken into account for estimate and subsequent analysis. Results: The participants who used a mobile phone for less than or equal to 1 hour, 41 individuals had a systolic blood pressure (SBP) ranging from 100 to 120 mmHg, while 3 individuals had SBP ranging from 121 to 140 mmHg. Among the participants who used a mobile phone for 2-3 hours, 73 individuals had SBP ranging from 100 to 120 mmHg, while 11 individuals had SBP ranging from 121 to 140 mmHg. There were 25 participants who used a mobile phone for ≤1 hour and had diastolic blood pressure (DBP) between 70-80 mmHg. Additionally, there were 20 participants who had DBP between 81-90 mmHg. Among the 41 participants who used a mobile phone for 2-3 hours, their DBP was between 70-80 mmHg, while 44 participants had a DBP between 81-90 mmHg. A total of 44 subjects who used mobile phones for ≤1 hour had a total leukocyte count (TLC) ranging from 4000 to 11000 per cubic millimeter (Cumm), while only 1 subject had a TLC exceeding 11000 per Cumm. Additionally, 84 subjects who used mobile phones for 2-3 hours had a TLC ranging from 4000 to 11000 per Cumm, with 1 subject having a TLC of 11000 per Cumm. Conclusion: The majority of the participants in our research exhibited a WBC total count within the normal physiological range, with the exception of two subjects whose WBC total count was determined to be elevated above the normal range. This research shows that prolonged usage of mobile phones might affect and alter the autonomic balance, leading to an increase in sympathetic tone.