Background:An autopsy is a medical technique that helps detect the physiological changes happening in the organs, therefore establishing the cause and time of death. Studying both the pre-death and post-death aspects of death is also beneficial. The significance of the research lies in its identification of the many types of abnormalities seen in the lungs and livers during medico-legal and neonatal autopsies, as well as via histological investigation. These abnormalities may have been either accidental findings or directly responsible for the cause of death.Aim:To investigate the histopathology of the lungs and liver in cases of individuals who were brought dead to a tertiary care center. Material and methods: Retrospective descriptive research was conducted at the Department of Forensic Medicine to analyze medico-legal autopsies. This research covered medico-legal autopsies conducted throughout that era, regardless of the age and gender of the individuals. Due to the medicolegal nature of the instances, ethical approval was not obtained. During the research period, a total of 50 medico-legal autopsies were performed. As part of these autopsy, samples of the lung and liver were submitted for pathological investigation. The whole specimen was sent to the department, conserved in a 10% formalin solution, accompanied with clinical particulars and macroscopic observations. The tissues underwent processing for histological testing. The histological sections were stained using Haematoxylin and Eosin stain and then inspected.Results: There are 37 males, which makes up 74% of the total, and 13 females, which makes up 26% of the total. The majority of the participants fell into the 20-30 age group, including 15 individuals (30%). This was followed by the 30-40 age group with 13 participants (26%), the 40-50 age group with 13 participants (26%), the below 20 age group with 5 participants (10%), and the over 50 age group with 4 people (8%).The majority of the specimens exhibit diffuse alveolar edema and congestion, accounting for 36% of the cases. This is followed by bronchopneumonia with numerous lung abscesses at 18%, bronchopneumonia at 16%, tubercular pneumonia at 14%, emphysema at 12%, and interstitial pneumonia at 4%.The majority of the specimens showed sinusoidal and vascular congestion, accounting for 48% of the cases. Cirrhosis was seen in 16% of the cases, chronic hepatitis in 12%, steatosis in 8%, CVC liver in 8%, epithelioid cell granuloma in 4%, and adenocarcinoma liver in 4%.Conclusion: This research emphasizes the significance of histological reports in lung and liver autopsy cases, particularly in instances when the histopathology results were unexpected and not taken into account at the time of death.