Background: The articulation of the maxilla and hard palate is where the greater palatine foramen (GPF) is seen. The GPC (greater palatine canal) continues upward and posteriorly and has an entrance in the pterygopalatine fossa. After leaving the foramen rotundum, the maxillary nerve reaches the pterygopalatine fossa, where it may be blocked with a high degree of success and minimal risk. This nerve block is essential for a number of oral surgical operations. Aim: The purpose of the study was to precisely identify the larger palatine foramen's patency, form, and location in Indian participants so that it might support the intraoral maxillary nerve block technique. Methods: The molar relationship and the patency and form of the larger palatine foramen were evaluated in 60 dry skull bones from adult adults of both genders. The gathered data were evaluated statistically. Results: The study's findings showed that, in 91% of the examined skulls, the larger palatine foramen was located bilaterally opposite the third molars on every skull. 54% of the skulls were discovered to be oval in form, and 96% of them were determined to be patency. Conclusion: The study's comparison and analysis of the data demonstrated that the racial perspective can affect the larger palatine foramen's patency, shape, and location. Keywords: Greater palatine canal, Greater palatine foramen, Maxillary nerve, maxillary nerve block, pterygopalatine fossa, regional blocks