Background: Cardiovascular diseases remain a leading cause of mortality globally, making adherence to medication guidelines critical in primary care settings. This study explores the awareness and adherence levels of primary care physicians to cardiovascular medication guidelines.Objectives: To assess the degree of awareness and adherence to cardiovascular medication guidelines among primary care physicians and to identify factors influencing these aspects.Methods:Design: Cross-sectional study.Setting: Various primary care clinics.Participants: 200 primary care physicians were selected through stratified random sampling. Data Collection: Survey questionnaire focusing on awareness and adherence to cardiovascular medication guidelines. Analysis: Statistical analysis using chi-square tests for categorical data and logistic regression for identifying factors influencing adherence. Results: The study found that 73% of primary care physicians were aware of cardiovascular medication guidelines, but only 62% adhered to them. Key factors influencing adherence included Years of Practice, Access to Resources, and Continuing Education. Barriers to adherence were guideline complexity, physician workload, and patient compliance challenges.Conclusions: The research underscores the need for improved strategies in educating and supporting primary care physicians to adhere to cardiovascular medication guidelines. Efforts should focus on addressing identified barriers and promoting regular guideline updates.