Background:Chronic kidney disease has become a global burden on the health service system and has been recognized as a major threat to humans, particularly in reducing quality of life (QOL) in the later stages of the disease. The study was conducted to assess impact of chronic kidney disease on quality of life of patients. Material & Methods:The sample size was 100 patients. The participants were interviewed to complete a structured questionnaire, which included demographic and clinical information as well as a KDQOL-SF scale with 36 items. Statistical Package for Social Sciences (SPSS) Version 21.0 was used to analyze the study results. Results:The Physical function mean was 57.65 ± 13.66; physical role 57.63 ± 12.45; body pain 52.85 ± 12.40; and general health 560.24 ± 13.45. The emotional wellbeing mean score was 59.48± 11.95; emotional role 60.60 ± 12.62; social function 57.75 ± 12.25; and energy/fatigue 557.39 ± 13.10. These results were highly significant (p < 0.0001). The summary score of the KDQOL-SF scale shows that; the PCS mean score was 58.64 ± 2.89 and the mean MCS score 58.45 ± 1.29. Conclusion:The study concluded that the mean score of the QoL for patients with CKD was lower in the hospitalized patients. Therefore, necessary measures should be taken to improve the QoL of patients.