Background: As on today, JN-1 is the most prevalent SARS COV- 2 variant globally. It is a descendant lineageof Omicron BA2.86subvariantand presents with symptoms of cough, fever and breathlessness, but with in a time span of 2 months that is between December 2023 and 9th February 2024, 79,107 patients were diagnosed worldwide and about 35,000 deaths occurred. The first Indian case of JN-1 COVID was reported on 16th December 2023, in Kerala, but almost all states have reported cases to date. Aim and objectives: To study the Clinical Features and Radiological findings and Outcome in JN-1 variant infected patients in a COVID ICU and to document the various comorbidities and vaccination status of these patients which influence the outcome. Methodology: All patients who tested COVID-RTPCR positive at the Respiratory Medicine OP/ Emergency Department,at Government General Hospital Nellore, (AP) between December23rd, 2023 and February 20th, 2024 and admitted in the COVID ICU with Respiratory Failure or having comorbidities were taken up for the Study. A good history was taken, all blood investigations, Chest x-ray ,CT scan chest, ECG, 2-D Echo were done. Physicians and Neurologist were referred to when necessary. The Swabs were further sent to INSACOG,Vijayawada for genome analysis. Results: A total of 8 patients -7men and 1 woman tested positive for COVID by RTPCR test in the 2-month period, all of them later confirmed to be JN-1 variant positive. 2 patients were sent for Home Quarantine as their only symptom was a low grade fever.6 other patients, most of them having multiple comorbidities were admitted in the COVID ICU, 4 of them were in Respiratory failure - 3 were started on oxygen and 1 on Mechanical Ventilator.The commonest co-morbidity was Destroyed or Damaged lung due to Old Pulmonary TB,or Severe COPD followed by Neurological disease CVA and Renal Failure. All patients had changes in CT-CHEST -ground glass shadows with Fibrobronchiectatic changes was the commonest finding. 2 patients were discharged with normoxemia, but 4 succumbed to the disease. Conclusions: As per our study, the JN-I variant of SARS-COV causes fatal disease in those with multiple co-morbidities, especially those with preexisting destroyed or damaged lungs and neurological disease. In those with healthy lungs,it passes off as a mild upper respiratory disease.