Introduction- Thalassemia is an inherited blood disorder, ranging from thalassemia major to minor. The disease is completely preventable if community awareness can be generated. The study was done to assess the awareness regarding thalassemia among the Higher Secondary School teachers and to find out the effect of a structured awareness materials on awareness of Higher secondary school teachers regarding Thalassemia. Materials & Methods- A community-based Intervention Study method was followed with a sample size of 110, using a structured interview schedule. After interview intervention was given as a form of structured awareness material and again knowledge regarding thalassemia was assessed after the post intervention. Result- Means of pre-intervention and post intervention knowledge score are respectively 25.62 and 37.17; mean difference of knowledge score is 11.55. While 66% respondent are below median knowledge score in preintervention, 44% are above or equal to the median score. There is significant difference in knowledge scores from the other studies which may be due different socio demographic status. Conclusion- after the intervention, comparison between pre-intervention and post-intervention total knowledge score shows significant increment in knowledge score. This study findings also show intervention with a structured awareness material can be effective for the high school teachers.