Introduction: The histopathological classification's criteria are clear, accurate, and include consideration for immunological manifestations, allowing it to successfully overcome the challenges associated with leprosy diagnosis, whereas the clinical classification solely focuses on the outward appearances of the lesions. Thus this study aim was to assess the Clinical characteristics and histopathological manifestations in leprosy. Materials and Methods: The histopathologic analysis of each biopsy's results and the clinical diagnosis of the leprosy cases (as supplied by the department of Dermatology) were correlated. Hematoxylin and Eosin- and modified Fite–Faraco (FF)-stained slides were examined by two investigators for changes in the epidermis, dermis, presence of granulomas, lymphohistiocytic infiltrate, epithelioid cells, Langhans giant cells, nerve involvement, and presence of acid-fast bacilli (AFB). Results: The distribution of 139 cases on the clinicalleprosy spectrum based on Ridley-Jopling scale revealed maximum cases 64 (52.3%) in borderline group(BT{25.4}+BB{11.9}+BL{16.4}).Inpolar groups, 34 (28.8%) cases belonged to TT and 19 (14.2%) to LL.9 (6.4%)caseswereofENL,5 (3.2%) of histoid leprosy, 2(0.9%) of indeterminate and 2(0.9) was inconclusive. No cases were found of type 1 and pure neural in our study. Conclusion: It is advised that clinical and histological aspects be correlated for precise type and treatment to lower morbidity in leprosy patients and their families