Background: There has been a lot of study done in this area on preeclampsia because it is one of the main causes of maternal death and pregnancy-related complications. The study's primary goal was to assess and contrast the levels of zinc and calcium in the serum in preeclamptic and healthy pregnant women. Materials and Procedures: This was carried out at the Department of Biochemistry, Index Medical College, Indore, Madhya Pradesh, India. 40 preeclamptic patients were assigned as case, while 40 healthy pregnant women with similar ages were assigned as control. Result:Participants' serum levels of zinc and calcium were examined, and the study group's levels were noticeably lower than those of the control group. According to the study's findings, pregnant women who have lower serum levels of calcium and zinc may be at risk of developing preeclampsia. Conclusion: Preeclampsia may thus be prevented by early assessment of these minerals' serum levels during prenatal visits and, if necessary, supplementation.