Background: Dry socket is the most frequent extraction-related complication, and it depends on a number of variables. The present study was conducted to evaluate the risk factors associated with formation of dry socket. Materials & Methods: 250 patients requiring extraction of mandibular third molars of both genders were enrolled. Risk factors such as gender, smoking, and systemic diseases etc. were recorded. Results: Out of 250 patients, males were 140 and females were 110. The age group <18 years comprised of 60 males and 30 females, 18-28 years had 25 males and 35 females, 28-38 years had 35 males and 28 females and >38 years had 20 males and 17 females. The difference was non- significant (P< 0.05). Among dry socket patients, smokers were 42. Out of 140 males, 38 males and out of 110 females, 24 females had dry socket. Systemic diseases were seen in 35 patients. The difference was significant (P< 0.05). Conclusion: Mandibular third molar tooth extraction is frequently linked to dry socket. Risk factors included smoking, being a woman, and having systemic disorders.