Background: Due to the advances in orthopedic and trauma-care, such as modern imaging methods, improved surgical techniques, and optimized design of implants and materials, patients are successfully treated. Hence; the present study was conducted for assessing the cases of traumatic orthopaedic related infections. Materials &Methods: A total of 100 patients were enrolled in the present study. Clinical data were combined, verified, and statistically evaluated. The data included accessible demographics (age, sex, white blood cell counts, etc.) and full laboratory findings (pathogen identification, antibiotic susceptibility testing (AST) results, etc.). Clinical specimens were gathered using a set procedure. Standardized laboratory bacteriology techniques were used to identify the bacterial isolates. Following the identification of the infections, the proper AST was carried out and antibiotic break-points were interpreted. Results: A total 100 cases of ORI were enrolled, resulting in the recovery and identification of 160 bacterial strains. From the 60 isolates, it was determined that 110 bacterial specimens would undergo AST testing. All the specimens underwent antibiotic susceptibility testing. Mean age of the patients were 53.9 years with majority being males. staph aureus was susceptible to chloramphenicol and gentamycin. Staphylococcus (Coag-negative) was susceptible to chloramphenicol, ciprofloxacin, clindamycin and gentamycin. Streptococcus spp, were susceptible to cefepime, ceftriaxone, clindamycin and gentamycin. Conclusion: Poorly developed public health systems with inaccurate data maintenance, poor post-operative wound care and hygiene, inadequate microbiological diagnosis, and a lack of appropriate antibiotic therapy to treat infections are just a few of the challenges that developing nations face and are typically overlooked by the developed world.