Background:Burnout among medical students is a pervasive issue, stemming from the demanding nature of medical education and its associated stressors. Mind-body interventions, such as yoga and meditation, have emerged as potential strategies to mitigate burnout symptoms. This study aimed to evaluate the effectiveness of a yoga and meditation intervention in alleviating burnout among medical students. Methodology: Using a randomized controlled trial design, participants were recruited from Ashwini Rural Medical College, Maharashtra, India. The study included 300 medical students, randomly assigned to either an intervention group, participating in a 12-week structured yoga and meditation program, or a control group. Baseline and post-intervention data were collected using the Maslach Burnout Inventory-Student Survey and a demographic questionnaire. Results: The findings indicated significant reductions in emotional exhaustion, cynicism, and diminished personal accomplishment in the intervention group compared to controls post-intervention (p < 0.05). Linear regression analysis confirmed the intervention's independent positive impact on burnout symptoms (p < 0.05). Notably, gender disparities were observed, with female students exhibiting higher burnout levels.This study provides robust evidence supporting the efficacy of yoga and meditation interventions in alleviating burnout among medical students. Recommendations include integrating such programs into medical education curricula and institutional wellness initiatives. Further research is warranted to explore long-term effects and applicability across diverse student populations. Conclusion: The study underscores the importance of addressing burnout among medical students and highlights the potential of mind-body interventions like yoga and meditation in promoting student well-being. By prioritizing mental health support, institutions can foster a healthier learning environment for future healthcare professionals.