Background:One of the main reasons for long-term restorative failure and replacement is caries recurrence. Research has been done on the addition of antibacterial agents to restorative materials in an effort to create medicinal materials with better biological characteristics. The present study evaluated antimicrobial efficacy of hydrophilic sealants. Materials & Methods:The antibacterial effect of both sealants was tested both through planktonic growth inhibition test – 96-well microtiter plates and agar disk diffusion assay. Results: Even at its lowest dose (10 μl), EmbraceTM demonstrated a greater and more comprehensive efficacy against all tested bacterial strains (P < 0.05) in the planktonic growth inhibition test, with inhibition rates consistently exceeding 90%.UltraSeal XT® does not show growth inhibition activity against Streptococcus species. Conclusion: Prescribing oral probiotics first and putting off the Embrace™ sealant application to the end of probiotic treatment.