Objective: This study was done to compare the clinical and histological healing of surgical wounds in cases of alveoloplasty when wound closure was done by Isoamyl 2-cyanoacrylate adhesive and 3-0 Mersilk. Methodology: This randomized prospective split mouth study was conducted on 35 patients requiring bilateral alveoloplasty on the mandibular anterior region. The wound was divided into two equal lengths and each half was randomly assigned as Group1, where surgical incisions were closed with sutures and in Group 2 closed with isomyl-2-cyanoacrylate. Wound healing was assessed clinically by 2 independent observers on 3rd, 7th, 14th and 21st postoperative days. Out of 34 subjects, 17 randomly underwent biopsy on 7th day and 14th day postoperatively for histological evaluation by 2 independent observers. Results: Erythema was more in cyanoacrylate at 3rd day but had less erythema on 7th and14th day and on 21st day Cyanoacrylates and sutures had similar observations. Tenderness was less in Cyanoacrylates on 3rd postoperative day and similar in all the post operative days. Wound healing was better in Cyanoacrylates in 3rd, 7th, 14th day and 21st day according to Wound Healing Index. Inflammatory cell infiltration was higher in sutures on both 7th and 14th day. On 7th day sutures had more vascularity and on 14th day both were having similar vascularity. Fibroblastic activity was more in Cyanoacrylates on 7th but on 14th day suture had more fibroblastic activity. Conclusion: The result suggested that isoamyl-2-cyanoacrylate has better initial healing compared to suture and was easy and safe to use.