Aim: To evaluate the impact of autologous platelet-rich plasma on chronic non-healing ulcers. Materials and Methods: This research is prospective and includes 50 patients who reported with persistent non-healing leg ulcers to the General Surgery department. This trial included patients aged 18 to 75 years with chronic non-healing ulcers that had been present for over 4 weeks. Patients must have already tried conventional treatments for at least 4 weeks, had ulcers less than 5 cm in size and a hemoglobin level over 10g/Dl were included in this study. Results:Out of the 50 patients, 35 were male (70%) and 15 were female (30%). Chronic lower leg ulcers were more prevalent in men than in females.The ulcer's length varied from 4 to 8 weeks, with an average duration of 5.55 weeks, as shown in table 2. 12 patients (24%) had a length of less than 4 weeks, whereas 38 patients (76%) had a period of 5-8 weeks. 38% of the ulcers were traumatic (19 ulcers) and 62% were spontaneous (31 ulcers). Spontaneous ulcers were more prevalent in the research. The most prevalent location was the Medial Malleolus. Itwasatallweeksfrom1st to last weekthep-valuewashighlysignificant(p<0.05).ThisclearlyshowtheimportanceofPRPandtheability of healing of ulcers. The mean duration of healing of the ulcers was in 4.11±0.65weeks. The mean percentage improvement in the area & volumeoftheulcerat3rdweekwas80%&90%.Similarly,at6thweekwas98%&100% respectively.In this study, ulcers treated with PRP had betterwound contraction of mean 8.87 ± 1.76 at 3rd week. Conclusion: Chronic non-healing ulcers are challenging to repair due to a deficiency in essential growth factors required for the healing process. Traditional treatments are inadequate for proper healing since they lack the key growth factors (PDGF, EGF, VGEF, etc.) required for the healing process. PRP is a secure, cost-effective, biocompatible, and straightforward in-office therapy for treating non-healing ulcers.