Background: To compare the ovulation induction rate of letrozole and clomiphene citrate in infertile women and the conception rate in both groups. Materials & Methods: One hundred fifty women in reproductive age (20-35yrs) were recruited. The male partner was also evaluated and semen analysis (based on WHO 2010 criteria) was done. Infertile women were randomized using a computer generated table in 2 groups-Group 1:-Women who received letrozole 2.5 mg to 7.5 mg for max 6 cycles and Group 2:-Women who received clomiphene citrate 50mg-150mg for max 6 cycles. The Chi-square test was used to compare the categorical variables. All the analysis was carried out on SPSS 16.0 version (Chicago, Inc., USA). Results: The correlation of ET on the day of trigger in clomiphene and letrozole group was found to be statistically significant (p<0.001), on application of t-test. The correlation of number of follicles on Day 14 in clomiphene and letrozole group was found to be statistically significant (p <0.001), on application of t-test, which shows that clomiphene does multi follicular development while letrozole does mono follicular development mainly. Conclusion: Higher pregnancy rate was found in letrozole treated cycle as compared to clomiphene it is statisticallysignificant (p<0.05)