Introduction: Anxiety, depression, and stress are common mental health issues that affect people in all walks of life. However, these issues can be particularly prevalent among students of medical college, who are often under immense pressure to excel academically and professionally. A number of studies have been conducted to assess the prevalence of anxiety, depression, and stress among medical college students, and the findings are cause for concern. There are fewer studies that assess the burden of depression, anxiety, and stress specifically targeting first-year medical students. Therefore it is important to have more studies concerning the mental health of medical students in their early years of medical school.Material and Methods: The present study is an Institutional based cross-sectional study conducted among students of medical college. The medical students from first year were recruited in this study. All the students available on the days of the data collection were included while the students who did not gave consent and the students who were absent during the day of data collection were excluded from this study. Results: The present study recruited a total of 186 medical students, comprising of more than 50% of male respondents followed by female respondents (48.9%). There was a significant different between variables like age, height and weight with reference to gender. However other variables like QIDS(quick inventory of depressive symptomatology), PHQ(patient health questionnaire), GAD(generalised anxiety disorder), PSS(perceived stress scale), k-scale (Kuppuswami socioeconomic scale) and BMI(body mass index) were statistically insignificant. Moreover, the PHQ, PSS and K - scale was higher among female respondents as compared to male respondents whereas the variables like GAD and QIDS were similar in both the groups. It was recorded that there was an insignificant association between levels of anxiety, depression, anxiety, and gender. However, socio-economic status was found to be statistically associated with stress, anxiety and depression. Conclusion: Mental health issues can lead to burnout, decreased empathy, and decreased job satisfaction, which can ultimately impact the quality of care that patients receive. Therefore, it is important that medical colleges take steps to address these issues, such as providing mental health resources and support, promoting work-life balance, and fostering a culture of openness and support.