Background Acute appendicitis is the most common cause of abdominal surgeries in all the age groups. The present study was conducted to compare intraoperative and post-operative outcome in laparoscopic vs open appendectomy in patients of acute appendicitis. Material & Methods: The present study was conducted in the Department of Surgery of MAMC, Agroha over the course of 12 months, from February 2021 to March 2022. After the diagnosis of acute appendicitis was made, allocation of patients for laparoscopic and open appendectomy was done. Intraoperative and post-operative outcome of both groups were noted. The collected data was analyzed with the statistical program Statistical Package for the Social Sciences (IBM SPSS, version 22). Results: The difference between the surgical times of the two study groups was found to be statistically significant on analysis (p-value 0.016). It was seen that the postoperative pain was significantly higher among the patients undergoing the open appendectomy as compared to those undergoing laparoscopic appendectomies (p-value 0.043). 32% of the study participants of the open appendectomy group and 28% of those of the laparoscopic group had postoperative incidence of vomiting. Open appendectomy was found to be associated with a higher proportion of postoperative wound infection, postoperative paralytic ileus. The mean time to return of bowel sounds for patients, the mean hospital stay for patients undergoing open appendectomy was higher than the patients undergoing laparoscopic appendectomy. Laparoscopic appendectomy was found to be associated with a lesser hospital stay.. It was found that the mean time to return to work for patients undergoing open appendectomy was 14.1±2.8 days, and that of the patients undergoing laparoscopic appendectomy was 8.2±1.4 days. Laparoscopic appendectomy was associated with a faster return to work, and the difference between the two study groups were found to be statistically significant on analysis (p-value