SARS COV-2 outbreak was over but individualsare suffering from internal damage caused by Virus during outbreak period. It is an enveloped, positive-strand RNA virus.There is very less information available about immune response developed after COVID infection.In this study we have analysed samples from individuals who have suffered fromCOVID-19 infection in recent past for evaluating various Co-morbid factor associated with IgG antibody production. We have found a significant observation of development ofIgG among person without Co-morbidity as compared to individualswith Co-morbidity. COVID-19 is caused by the SARS-CoV-2 virus and it was identified ed after an outbreak of Pneumonia in Wuhan, China in December 2019. Several risk factors are associated with the complications of COVID-19. The Immune system produces IgM, IgG, and Neutralizing antibodies which can block the virus from entering cells. Long term humoral response post COVID-19 infection is still not clearly known. Studies related to complete course of IgG antibody in COVID-19 infection are very sparse. The present study was therefore conducted to evaluate SARS COVID-19 antibody status of individuals in post COVID-19 OPD in Central India's population at our tertiary care hospital.