Introduction: Negative pressure wound therapy (NPWT) is a treatment modality in management of infected wound and compound injuries where primary closure is not possible. Conventional equipment’s for NPWT are expensive, so we developed an affordable low cost alternative for our patients. Aim of our study was to evaluate the clinical efficacy and cost effectiveness of our system using resources which are easily available in most hospitals with conventional NPWT system. Materials and Methods: Commercially available Sponge foam which is normally available at hardware stores is autoclaved and placed over wound. We used Ryle’s tube as connecting tube which is easily available and very cheap. Its perforated ends are kept over foam. Transparent adhesive film is used to provide air tight seal covering 2-3cm of surrounding skin Bedside suction machine system is used to create vacuum. Results: 46 patients were randomly allocated in both the group in which 29 were males while 17 were females. There was no significant difference in the rate of reduction of wound area as well as wound depth noted at 15 days in the Group A compared to the Group B. Conclusion: This study provides an alternative, easily reproducible and cost effective method to conventional NPWT and it’s equally efficient in wound management.