Background:Osteoarthritis (OA) is one of the most common degenerative disorders among the elderly population; although aging is the most important cause, research has shown that it is a complex disease with many etiologies. Objectives:The objective of this study was to assess the burden, socio-demographic features and risk factors of OA knee among the Indian population. Methods:A hospital based cross-sectional study was conducted in the department of orthopedics in a tertiary care center, India. All suspected patients of ≥ 50 years of age were enrolled. Knee OA was diagnosed using the clinical criteria laid down by the American College of Rheumatology (ACR). Data were collected included Socio-demographic variables, detailed past and family history associated risk factors, clinical presentation, local examination of both the knee joint and radiological investigation was done. Results:The prevalence of knee osteoarthritis was 25%. Higher in females: age more than 50 years. Obesity, family history of OA, physical inactivity and presence of comorbidity were found to be significantly associated with higher odds of OA knee (p<0.05). Pain in knee joint, bony tenderness, crepitus and morning stiffness were the common clinical presentation of knee OA. Conclusion:Elderly suffering from knee OA had significantly lower perception of their quality of life most affected is the psychological and physical domains of quality of life.