Background: Topical corticosteroids are commonly used after cataract surgery to decrease ocular inflammation. One of the common side effects of topical steroids include increased intraocular pressure (IOP). This study was undertaken to determine the incidence of increased intraocular pressure with the use of topical difluprednate 0.05%ophthalmic emulsion. Methods:This hospital based, prospective, observational cohort study was done over a period of three months. The study involved a total of 75 non-glaucomatous eyes of consenting, inclusion-eligible adults of uncomplicated cataract. The cases were operated by same surgeon by manual small incision cataract surgery. All patients were given difluprednate 0.05% eye dropat a starting dose of four times per day which was tapered over a period of four weeks. Evaluation of patients at follow up visits included Goldmannapplanation tonometryat various time points till fourth postoperative week. Appropriate statistical tests like descriptive statistics, paired t-test and chi square test were used. Results:Amongst the analyzed 65 patients with average age of 66.4 years, 62% were males and 38% females. Average baseline IOP was 14.4 mmHg. Rise in IOP above 20mmHg was found in three subjects (4.6%). Of these, one patient had an increase in IOP that was 5mmHg above baseline (>20% over baseline). IOP was managed by discontinuation of difluprednatedrop. All patients responded to treatment returning to baseline. Conclusion:Patients receiving topical ocular steroids, especially difluprednate have to be followed regularly with IOP monitoring. Caution need be exercised for steroid-responders and the drug discontinued on elevation of IOP.