Background: Several diseases can present with necrotizing non-granulomatous lymphadenitis. The present study was conducted to assessclinicopathological spectrum of necrotizing lymphadenitis. Materials & Methods: This is a retrospective study to assess clinicopathological spectrum of necrotizing lymphadenitis. A total of 48 cases of necrotizing lymphadenitis diagnosed on lymph node biopsies over the 2 year period, were reviewed. Clinical details of all the cases were collected from electronic medical records and patients were followed up for a minimum period of 6 months. Results: A total of 48 cases of necrotizing lymphadenitis diagnosed pathologically were further categorized based on serological tests. 16.66% proved to be lupus lymphadenitis and 18.75% were EBV lymphadenitis. 64.58% with negative serological tests were classified as Kikuchi lymphadenitis. Lupus cases had a female preponderance (75%). Males (75%) were commonly affected by EBV lymphadenitis.Kikuchi lymphadenitis also was seen mostly in females (61.29%). Conclusion: The present study concluded that Kikuchis lymphadenitis is the most common cause of necrotizing lymphadenitis, followed by lupus and acute EBV lymphadenitis.