Background:The Prevalence of current use of any opioid in India is 2.06%. Several studies point to the cognitive impairment in opioid abusers across various cognitive domains which often go undetected. Patients with Opioid Use Disorder, OUD exhibit poorer performance on neuropsychological measures of learning, memory, and visuospatial ability. Early age of onset and prolonged duration of exposure can be an important risk factor of cognitive dysfunction in these patients.Aims & objectives:Tofind out memory impairment in Opioid Use Disorder Patients and it’s correlation with age of onset and duration of opioid dependence.Materials & methods: A cross- sectional study on 40 OUD Patients was carried out from January 2021 to August 2022 with a focus on the prevalence of memory impairment in them. After taking informed written consent their different memory domains were tested using PGI Memory Scale and the results obtained were correlated with the age of onset and duration of opioid dependence.Results:In our study 30(75%) subjects had dysfunction present in Verbal retention for dissimilar pairs which was maximum among the other subsets.Considerable number of subjects had dysfunction present in Remote memory also 22 (55%). Minimum dysfunction was found in the recent memory 6(15%).We also found significant correlation between duration of opioid dependence and the mental balance. Other memory subsets failed to show any correlation with the age of onset and duration of opioid dependence.Conclusion: Assessment of memory impairment among OUD patients could be possible using PGI Memory Scale. Early intervention and knowledge of cognitive deficits in OUD Patients might help in their better management and expecting improved outcomes. Further more studies are needed be carried out in the same field.