Introduction: A rare condition known as rhino-orbito-cerebral mucormycosis (ROCM) manifests as both acute and fulminant symptoms. There are significant rates of morbidity and mortality linked to this infection. The present study was done among confirmed cases of rhino orbito cerebral mucormycosis to evaluate the clinical features, prognostic factors, and outcomes of this disease. Material & methods: The retrospective study was done among 50 cases of rhino orbito cerebral mucormycosis at a tertiary care centre for a period of one year. All of the clinical and demographic details, including underlying diseases, and ocular and neurologic symptoms were examined. Data was analyzed using SPSS version 25.0. Results: The mean age of patients was found to be 53.1±10 years. Patients 46% had diabetes, 22 % had hematological disorders, 18% had thalassemia and 14% had beta cell lymphoma. The most common symptoms were periorbital swelling, and ocular pain found in almost 80% of cases.74% of cases survived whereas 26% did not survive. Conclusion: It is believed that uncontrolled diabetes mellitus is the predisposing factor for ROCM. It is advised to diagnose this acute disease as soon as possible using a biopsy and clinical symptoms to prevent and lower the mortality rate.