Aim: The objective of the present study was to examine levels of overall and aspects of Oral Health-Related Quality of Life in a cohort of patients with OLP using both an OLP-specific Quality of Life instrument (COMDQ-15) and non-specific oral health-related QoL instrument (OHIP-14).Methods: This cross-sectional study comprised of 100 patients was conducted at Shri Shankaracharya institute of medical sciences, Chhattisgarh and the study was approved by ethical committee. Patients with clinical and histopathologically confirmed OLP based upon modified WHO diagnostic criteria were included. Demographic characteristics were collected, included gender, age, patient types and the lesion duration since the first diagnosis of OLP, using dental records. For the clinical characteristics, OLP lesions were recorded for localization (buccal mucosa, tongue, lip, gingiva, palate, floor of the mouth and soft palate), types (reticular, atrophic, erosive/ulcerative, bullous, pigmented and plaque type), and clinical severity classified by the Thongprasom sign scoring system.Results: The study group consisted of 80 women (80%) and 20 men (20%). The mean age was 55.1±13.9 years. Sixty-two of them (62%) had OLP lesions for 1-5 years; 20% for more than 5 years, and 18% less than 1 year. Almost all patients (95%) complained of having pain. However, mean pain intensities were mostly mild (60%), followed by moderate (38%) and severe (2%). The mean NRS pain scores were 2.56 ±2.32. Ninety-six percent of OLP patients had oral symptoms and their influence on daily activities on their daily performance. The most prevalent impacted performance was eating (86%) followed by cleaning the oral cavity (65%) and emotional stability (62%). In addition, there were also symptoms and their influence on daily activities on social activities (16%) and smiling (15%). Although the overall prevalence of oral symptoms and their influence on daily activities was high, the mean overall percentage score was low (12.1 ±13.3, range 0-77.5). The highest mean performance score was that of eating (8.1 ±6.8), followed by cleaning the oral cavity (6.6 ±7.5) and emotional stability (5.3 ±7.2). A correlation analysis showed a statistically positive association between clinical severity and the intensity of oral symptoms and their influence on daily activities (rs = 0.490, p < 0.001). The intensity of oral symptoms and their influence on daily activities increased for each step, increasing in clinical severity scores between 2 and 4. Oral symptoms and their influence on daily activities were perceived as little, moderate and severe to very severe intensity with clinical scores of 2, 3, and 4 respectively.Conclusion: The current study demonstrated that nearly all patients had oral symptoms and their influence on daily activities. The impacts were frequently related to eating, cleaning the oral cavity and emotional stability. There were significant associations between OLP clinical signs and OHRQoL, as well as OLP pain perception among OLP patients.