Background and objective: One of the most well-known issues with public health is dengue illness linked to considerable morbidity in both the tropics and the subtropics. This study aimed to investigate the dengue trend and identify the dengue seasonal pattern. Material method: The present prospective cross-sectional study was conducted for a period of one year in the department of microbiology at MGM Medical College, Indore, Madhya Pradesh, from 2020 to 2021. Blood samples were received from 450 suspected dengue patients for ELISA testing to detect the NS1 antigen. Result Serum samples from 450 patients who had fevers thought to be caused by dengue infections were collected. In the current study, 45(10%) patients tested positive for dengue using NS1 ELISA. 45 samples were found to be positive. Six cases tested positive from January to April, and seven cases tested positive from May to August. However, majority of the instances between September and November were found to be positive. Conclusion: This study emphasises the need for continuous surveillance coupled with a vector control programme and awareness among the public in combating future dengue epidemics.