Background:A post operative surgical site infection in spine surgeries is a potentially devastating complication . The present study was conducted to assess the efficacy of Intrawound application of vancomycin powder with systemic cefuroxime (postoperatively) on post operative wound infection in spine surgery with metallic implant fixation.Material & methods:Study drug was allocated into two groups as: Group A- Intra wound application of local vancomycin powder with post operative systemic antibiotics in patients of spine surgery and Group B - Post operative use of systemic antibiotics in patients of spine surgery. Findings were noted. All the results were summarized in Microsoft Excel sheet. P value<0.5 was considered as significant. Results:On comparing both the Groups with respect to co-morbidities along with SSI’s, non significant results were obtained (p=0.32). On comparing the Post operative discharge among Group A and Group B ,significant results were obtained with p value=0.037.On comparing both the Groups with respect to pathogens and post operative fever, non significant results were obtained. The number of cases showing pathogens in pus and culture sensitivity report of patients who developed SSI’s was less in Group A. On comparing the Post operative Wound status among Group A and Group B ,significant results were obtained with p value=0.037.Conclusion: The study concluded that there was significant reduction in surgical site infections observed in patients of spine surgeries with metallic implant fixation in whom combined therapy was given.