Background: Tympanic membrane perforation is a common otological disorder with associated hearing impairment. Despite the high prevalence of chronic otitis media (COM) in low to middle-income countries, there are few studies regarding its associated factors, health-related quality of life, and treatment costs. Aim: This study aimed at determining the socio-demographic and clinico epidemiological pattern of tympanic membrane perforation in a tertiary hospital, New Delhi. Methods: This cross sectional observational study was carried out in ENT Department at Jaipur Golden Hospital, New Delhi. Patients of 12 to 45 years of age, central tympanic perforation with intact ossicular chains and conductive deafness ranging from 25dB to 40dB were included in this study. Detailed history was taken and complete general and systemic examination was conducted and any relevant positive finding was recorded. Investigations like tuning fork test and pure tone audiometry was done for assessment of hearing loss. Results: Majority (46.25%) patients were in the age group of 21-30 years, predominantly male (62.5%). Most of the cases 64 (80%) had unilateral involvement, among that 33 (41.25%) patients had right ear involvement, 31 (38.75%) had left ear involvement and 20% had bilateral ear involvement at the time of presentation. Hearing loss and ear discharge was the most common clinical presentation. Most common (60%) tympanic membrane perforation was medium size central perforation. Majority of cases (55.7%) had a conductive hearing loss between 21-30 db. Conclusion: Health awareness campaign, improved health education and easy accessibility to health care facilities can reduce the morbidity and mortality due to tympanic membrane perforation.