Abstract Issue

Volume 13 Issue 1 (January) 2024

Original Articles

Non-alcoholic fatty liver disease: prevalence and predictive factors- Experience of a tertiary care centre
Dr. Awanish Kumar, Dr. Anand Shankar, Dr. Manish Kumar

Background& Objectives:Non-alcoholic fatty liver disease or NAFLD is a liver condition which is highly prevalent, yet underappreciated and under-reported. As a spectrum of disease, this condition is characterized by accumulation of fat or steatosis in liver cells in the absence of other identifiable causes such as excessive alcohol consumption. Early intervention before the onset of fibrosis presents an excellent prognosis as the condition is largely reversible at this stage. However, if the treatment is delayed, fibrosis sets up that may further progress to end-stage liver disease or hepatocellular carcinoma which have a very poor outcome. It is therefore prudent that all efforts should be made to diagnose this condition early and the risk factors specifically targeted. Based on this background this study was conducted to study demography and predictive factors of this condition.Methods:This hospital based cross sectional study was conducted in medicine department of our hospital over 2 years from December 2021 to November 2023 targeting relatives of patients who didn’t give history of previous liver disease. Those who gave history of even occasional alcohol intake, diagnosed case of HBV or HCV, suffering from other known liver disease and those taking medications with a potential to cause chronic liver disease were excluded. Relevant demographic, anthropometric and medical data were recorded and focused laboratory investigations were done. All such participants underwent ultrasonography of liver to look for hepatic steatosis.Result:Over the study period 329 subjects were analysed. Among them 67 had evidence of NAFLD on USG and the rest 262 were apparently normal, thus giving a prevalence of 25.6% for NAFLD. The two groups didn’t differ significantly in terms of age, gender, dietary preference or hypertension. But patients with NAFLD had a significantly higher BMI as well as higher incidence of diabetes mellitus, ischemic heart disease and metabolic syndrome. Among the laboratory parameters, fasting blood sugar, total cholesterol, triglycerides and total cholesterol to high density lipoprotein ratio (TC/HDL) was significantly higher in NAFLD group as compared to the normal group.Conclusion:The prevalence of NAFLD is strikingly high in the general population. There is higher occurrence of increased BMI, diabetes mellitus and metabolic syndrome as well as increased fasting blood sugar total cholesterol and serum triglycerides in these patients.

 
Html View | Download PDF | Current Issue

Get In Touch

IJLBPR

322 Parlount Road Slough Berkshire SL3 8AX, UK

ijlbpr@gmail.com

Submit Article

© IJLBPR. All Rights Reserved.