Introduction: Lymph nodes are peripheral lymphoid organs and cervical lymphadenopathy is a common manifestation often overlooked. Proper and early diagnosis of lymphadenopathy is important for starting early and effective treatment as it requires further investigation with respect to its aetiology and diagnostic procedure since analysis of lymph node enlargement in the neck is difficult because most of the diseases resemble each other. Objective: Aim was to conduct a clinicopathological study of cervical lymphadenopathy with regard to age, sex, clinical mode of presentation and location of the lymph nodes, to study correlation between clinical and pathological findings and to emphasize the role of FNAC in etiological workup of cervical lymphadenopathy cases. Methods: The study was conducted among 126 patients visiting the ENT OPD &/or admitted in the IPD with Lymph node enlargements in the neck amongst other findings at “HBT Medical College and Dr. R..N. Cooper Municipal General Hospital,” Mumbai; during the period September 2020 through August 2022. Result: Present study majority of enrolled cases were diagnosed with tubercular lymphadenitis 71 cases [56.34%] and mostly belonged to age group of 21-30 yrs and majority were males [68]. Second most common clinical diagnosis was found to be reactive lymphadenitis 34 cases [26.98%] followed by secondary metastasis13 cases [10.32%]. Among secondaries, it was found that the primary carcinoma was most commonly of the oral cavity [SCC] (35.29%), followed by papillary carcinoma of thyroid (23.5%). Conclusion: Lymph nodes are strategically placed along the drainage of tissue and body fluids. The enlargement of these is a worrisome sign as there are multiple etiological agents and are common portal for the spread of infection and malignancy, so early diagnosis of lymphadenopathy is important for starting of early and effective treatment. FNAC is considered to be the first line invasive test for any case with cervical lymphadenopathy as its easy to perform , widely available , have high sensitivity and confirms clinical diagnosis accurately, especially when it comes to identifying tubercular lymphadenopathy. Though open biopsy with histopathological examination is definitive investigation particularly in diagnosing malignant cases.