Background: Recent research has highlighted a concerning trend of increased long-term mortality rates among burn injury survivors compared to the general population. This study aims to deepen the understanding of the long-term health implications for these individuals, focusing on both physical and psychological aspects. Methods: A retrospective cohort study was conducted, involving 65 burn survivors and 325 control subjects. Participants were selected based on the National Academy of Burns India guidelines, with a focus on major burns. Data were collected from various administrative databases and analyzed using SPSS software. The study considered variables such as age, sex, comorbidity scores, and socioeconomic factors. Results: The study found that burn survivors had a higher overall mortality rate (27.9 per 1000 person-years) compared to controls (11.8 per 1000 person-years). The 5-year mortality rate was 10% for burn survivors, against 3% for controls. Burn survivors also exhibited higher mortality rates due to trauma, mental illness, and cirrhosis. The risk of death was highest in the first year post-injury and remained elevated over five years. Conclusion: Burn survivors face significant long-term health challenges, including increased mortality rates and heightened risks of specific health complications. Recommendations: The study underscores the need for comprehensive, long-term care and support for burn survivors, with a focus on addressing both physical and psychological health needs, and considering the impact of socioeconomic factors.