Introduction: Renal changes result in a general decline of health characterized by a physiological imbalance that has a significant impact on the quality of life of persons with the condition.As a result, an attempt was made to investigate the oral and dental symptoms of chronic renal failure in type 2 diabetes patients undergoing hemodialysis.Materials & Methods: The present study is the hospital based analysis done on 200 individuals. The included patients were divided into two groups: Group A consists of 100 patients diagnosed with chronic renal failure along with type 2 diabetes and Group B consisted of 100 healthy individuals. Detail history along with the demographic data was collected of all the included patients.Results:Poor oral hygiene, dryness of the mouth, taste changes, and paleness of the mucosa were observed to be more common and severe in group A patients than in group B. Gingivitis, periodontitis, dry-fissured lips, and oral ulcerations were some of the less prevalent signs. Gingivitis (p = 0.531) and periodontitis (p = 0.191) were likewise not substantially different in the two groups; however, they were somewhat greater in the diabetes group than in the nondiabetic group.Discussion & Conclusion: This study found a higher frequency of oral and dental symptoms in individuals with chronic renal failure and type 2 diabetes than in healthy controls. The oral health condition of CRF HD patients deteriorates as the duration of CRF increases. As a result, oral health maintenance is critical in this patient population. The dialysis team and dentists should promote the oral health maintenance awareness programme for CRF HD patients.