Introduction:Pain is a more dreadful ruler over humanity than death. Postoperative pain management is crucial for providing rapid relief from pain after surgery. This can be achieved by the use of several methods such as systemic analgesics (either orally or parenterally), epidural analgesia, local infiltration at the surgical site, and local nerve blocks. Epidural pain relief with local anaesthetic drugs is a widely used, straightforward, efficient, and cost-effective method of delivering pain relief after surgery.Material and Methods:This study was a future comparative randomised study undertaken in the anaesthesia department of tertiary care institutions in Haldia. Following permission from the ethics committee, a total of 100 patients who were scheduled to undergo elective procedures on their lower limbs or lower abdomens were enrolled in the study. The inclusion criteria included of patients who were classified as ASA I and II, aged between 18 and 45 years, and included both male and female individuals.Results:The distribution of weight was similar in all three groups. The beginning of pain relief was quicker in the Fentanyl group compared to the other two groups, and this difference was statistically significant (p = 0.000). The time it took for pain relief to start in the Buprenorphine group was substantially longer compared to the other two groups, according to statistical analysis (p = 0.000). The length of pain relief was longest in the Buprenorphine group, and this difference was statistically significant compared to the other groups (p=0.000). The length of pain relief was the shortest in the fentanyl group, which was statistically significant when compared to the other groups (p=0.000). The number of doses was lowest in the Buprenorphine group, followed by the Tramadol group, which required less doses than the Fentanyl group. G. Ozalp, F. Guner and coworkers (1998) conducted a study to assess the effectiveness and safety of patient-controlled epidural analgesia using morphine or fentanyl in combination with Bupivacaine for relieving postoperative pain. They determined that both approaches were successful in pain prevention, although due to less adverse effects, Fentanyl might be considered more favourable than Morphine.Conclusion:The current investigation indicates that the quality of pain relief was similar among the three medicines. Fentanyl has the quickest onset of pain relief, but because it doesn't last as long as tramadol and buprenorphine, it needs to be administered more often. Buprenorphine has a longer duration of pain relief and hence requires fewer dosages compared to tramadol and fentanyl.