Background:This study examined how often head and neck cancer patients who receive radiation develop middle ear infections. It is crucial to keep a close eye on patients with head and neck malignancies who are undergoing concurrent chemoradiotherapy as they are found to have a high incidence of otitis media with effusion. This emphasizes the importance of carefully monitoring and managing this condition for a better quality of life and treatment outcomes.Design – At a tertiary care hospital, this prospective case control study was conducted. Methods: Detailed otoscopy and immittance evaluation were done for all the patients with HNC who were receiving concurrent chemotherapy and then follow-up were studied at completion of CCRT and at 12 weeks. The study included 100 patients in all.Results- In the after 6 weeks of CCRT, CSOM, post-irradiation OME, were all caused byEBRT. 31% of cases were found to have B type of tympanogram indicating Otitis media effusion and 26 % had ‘C’type indicating ET dysfunctioning. After 12 weeks of CCRT, 3% got ‘B’ type indicating Otitis media effusion and 5 % had ‘C’ type indicating ET dysfunction. These findings suggested that, when compared to the results of conventional radiotherapy, the External beam radiotherapy approach demonstrates the ability to reduce the incidences of OME and ET dysfunctioningThere is a considerablepercentage of head and neck malignancy cases who develop OME post RT, however, in most of them it resolves spontaneously.Conclusion-With further research, we can determine the optimal strategies to minimize the impact of otitis media with first visit follow up on these patients and help them in their fight against cancer.