Introduction: The classical treatment plan for the edentulous patient is the complete removable maxillary and mandibular denture. However, in recent years, the two-implant mandibular over denture has been proposed as anal ternative to more complex over denture designs. The incidence of mechanical complications including denture base deformation and fracture of denture has been reported in long-term clinical studies. The Purpose of this study was to evaluate and compare the influence of glass fibre and metal mesh reinforcement on denture base strain on two implant supported overdenture. Materials and Method: Eighteen experimental overdenture bases were fabricated for the evaluation of strain on their B&D positions(on top of the ball attachment) during load application. For strain measurements, total 4strain gauge, two strain gauge(2measuring directions, 0 and 90degrees) each were cemented at the crest and of B and D position. A universal testing device at a crosshead speed of 0.5 mm/min was used for strain measurements. Conclusion: E-glass fiber reinforcement placed over the residual ridge and implant attachment reduced denture base strains and deformation of two implant-supported overdentures by almost 50%. Metal mesh reinforcement placed over the residual ridge and implant attachment increases the base strain and deformation