Background: Brachial plexus block is the most commonly practiced peripheral nerve block. The present study was conducted to compare levobupivacaine withclonidine and levobupivacaine with dexmedetomidine in ultrasound- guided supraclavicular brachial plexus block for upper limb surgeries. Materials & Method: A prospective randomized double blind study was done in 90 patients with ASA physical status I or II to be operated under supraclavicular brachial plexus block of both genders were divided into 2 groups of 45 patients each. Group L+C, patients received levobupivacaine 0.5% (20 ml) 100 mg and 1.0 ml (150 mcg)clonidine. Group L+D, patients received levobupivacaine 0.5% (20 ml) 100 mg and 1.0 ml (100 mcg) dexmedetomidine. Parameters such as duration of surgery, onset of sensory blockade, motor block, duration of sensory blockade, motor blockade and duration of analgesia were recorded. Results: Group L+C had 28 males and 17 females and group L+D had 22 males and 23 females. The mean duration of surgery was 115.2 minutes in group L+C and 118.4 minutes in group L+D. The onset of sensory blockade was 6.1 minutes in group L+C and 3.7 minutes in group L+D. The onset of motor blockade was 9.2 minutes in group L+C and 8.3 minutes in group L+D. The mean duration of sensory blockade was 254.6 minutes and 435.8 minutes, duration of motor blockade was 290.2 minutes and 517.9 minutes. The duration of analgesia was318.5 and 752.1 minutes in group L+C and group L+D respectively. The difference was significant (P< 0.05). Conclusion:Dexmedetomedineis betterthan clonidine in terms of hemodynamic stability, analgesia as adjuvant tolocal anesthetic agent in supraclavicular brachial plexus block as it has prolonged duration of sensory and motor blockade alongwith increased duration of analgesia.